GABRG2 and epilepsy: The heterozygous Gabrg2+/Q390X knock-in mouse had a severe epilepsy phenotype that included spontaneous generalized tonic-clonic seizures and sudden death after seizures and accumulation and aggregation of mutant γ2(Q390X) subunits that may contribute to the chronic progressively declining clinical course of the epileptic encephalopathy (Kang et al., 2015).