ALB and type 1 diabetes mellitus: In the UKPDS, evolution from microalbuminuria to macroalbuminuria occurred at a rate of 2.8% per year, and change over from macroalbuminuria to renal dysfunction or ESKD occurred at a rate of 2.3% per year.Similar to what happened with type 1 diabetes; loss of GFR can occur at any level of albuminuria but tends to be more rapid with greater urine albumin excretion.