KDR and neoplasm: Tumor angiogenesis, i.e., perfusion and vascular density have been successfully measured in small animals by Doppler or contrast-enhanced US with microbubbles (non-targeted and targeted to, e.g., VEGFR2 (249), ανβ3-integrin, or endoglin) with a spatial resolution of ~50–100 μm (45, 52, 229).