Themedian lytic/latent ratios in the CD8+ EM T cell,CD8+ EMRA T cell, CD8+ CM T cell andCD8+ EM/EMRA T-cell subpopulations were also significantlylower in MS than in healthy subjects (Figure 4d).Furthermore, when we confined the analysis to HLA-A*02+subjects the median lytic/latent ratio in the CD8+ T-cellpopulation was only 1.38 in patients with MS compared with 9.31 inHLA-A*02+ healthy subjects (P=0.002) (datanot shown). This evidence concerns the gene CD8A and myeloid sarcoma.