The strongest physiological evidence for an ASC-caspase-8 containing inflammasome is the fact that Francisella tularensis activates a caspase-1 independent AIM2-ASC inflammasome to drive IL-18-dependent IFN-γ production.96 In the case of Salmonella infection, an NLRC4-ASC-caspase-8-caspase-1 inflammasome has also been shown to induce pro-IL-1β via caspase-8 and pyroptosis via caspase-1 activity.97 Overall it appears possible that ASC may recruit caspase-8 to trigger appropriate responses to a microbial insult. Here, PYCARD is linked to Salmonella Infections.