Like TNFR1, FAS and TRAIL-R signalling events are important for regulating pathogen clearance and immune responses, as well as for driving inflammatory disease via effects on cell viability and/or pro-inflammatory cytokine and chemokine induction.26 The critical role of Fas/FasL signalling in disease is highlighted by the autoimmune lymphoproliferative syndrome (ALPS) that occurs in patients harbouring Fas/FasL mutations, and C57BL/6.Faslpr and C57BL/6.FasLgld mice, respectively.3 Here, TNFRSF1A is linked to autoimmune lymphoproliferative syndrome.