For example, the IL-1β dependent murine K/BxN serum transfer arthritis model has been reported to be caspase-1-and MLKL independent, and is instead dependent on RIPK3 and caspase-8 for local and systemic IL-1β secretion during the resolution phase of disease.50 Results suggest that caspase-8 activity is required for optimal priming and may directly cleave IL-1β in this model. Here, CASP8 is linked to arthritic joint disease.