The contribution of RIPK3 and necroptotic signalling to a range of diseases reportedly driven by necroptotic signalling was recently re-examined by Newton et al.119 Contradicting previous findings, no role for RIPK3 and necroptosis was observed in acute pancreatitis, brain injury (major cerebral artery occlusion and hypoxia-induced cerebral oedema) or DSS colitis (Table 3).119 Differences in experimental procedures or the microbiome were suggested as plausible explanations for these discrepancies. The gene discussed is RIPK3; the disease is hypoxia.