AKT1 and fibrosis: Therefore, JDHY is a widely used therapeutic in, for example, antihepatic fibrosis where it functions by increasing antioxidant activities and reducing extracellular matrix protein production [17, 18]. Radix paeoniae rubrathe was found to relax vascular smooth muscles by regulating Akt and SOCE-eNOS-cGMP-mediated pathways [19].