DNMT3A and acute myeloid leukemia: Studies demonstrated that normal BCOR retains hematopoietic stem cells in a quiescent, undifferentiated state and loss-of-function BCOR mutations result in enhanced HSC cell proliferation and differentiation [80]. BCOR mutations occur in 3.8% of CN-AML, and DNMT3A mutations are detected in 43.5% of these patients. BCOR mutations tend to be associated with an inferior EFS and OS [81].