NPM1 and acute myeloid leukemia: In some other studies, however, patients with mutated IDH1 or IDH2R140 had good prognoses for OS in AML patients with the NPM1 mutation without FLT3ITD [27, 52], and it was further concluded that the favorable effect of NPM1 mutations was restricted to patients with cooccurring NPM1 and IDH1 or IDH2R140 mutations [27].