However, there is accumulating evidence for early alloHSCT being the only curative therapeutic approach for patients suffering from monogenic PIDs causing severe enteropathy, such as IL10/IL10R deficiency (26), the IPEX syndrome (27, 28), and CTLA-4 deficiency (29). This evidence concerns the gene IL10RA and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.