The use of vaccination targeting IL-1 extends now from initial rheumatic diseases, such as RA and crystal-induced arthritis (such as gout or acute chondrocalcinosis), to autoinflammatory diseases, such as systemic juvenile idiopathic arthritis (JIA), cryopyrin-associated periodic syndromes (CAPS), and familial Mediterranean fever (FMF). The gene discussed is IL1A; the disease is familial Mediterranean fever.