TSPO μPET with [18F]-GE180 as well successfully detected age-dependent neuroinflammation in APP/PS1dE9, another AD mouse model, and to a lesser extent in wild-type (WT) mice (Liu et al., 2015) and [11C]PBR28 showed increased uptake in 5XFAD mice compared to age-matched WT mice (Mirzaei et al., 2016). The gene discussed is TSPO; the disease is Alzheimer disease.