The results of TSPO imaging in vivo are strengthened by recent investigations in transgenic AD mouse models: [11C]PBR28 showed a 27% increase of brain uptake in 6 month old 5XFAD mice compared to WT mice, confirmed by autoradiograpy and immunohistochemistry (Mirzaei et al., 2016). This evidence concerns the gene TSPO and Alzheimer disease.