Another recent study showed that intraperitoneal administration of trodusquemine, a selective BBB-permeant (Ahima et al., 2002; Lantz et al., 2010) PTP1B inhibitor, relieved anxiety in LMO4 knockout mice exhibiting impaired endocannabinoid signaling due to increased PTP1B activity in amygdala (Qin et al., 2015b). The gene discussed is PTPN1; the disease is Anxiety.