Several In vivo studies have alluded to the protective effects of the antioxidants, such as lipoic acid (Yamamoto et al., 2001), Vitamin E (Yamazaki et al., 1993; Fryer, 2009), ascorbic acid and thioredoxin (Hawkins et al., 1995) against Cu-induced hepatitis in Long Evan Cinnamon rats an animal model of WD. Here, TXN is linked to Wilson disease.