Likewise, overexpressing FAD mutant forms of Presenilin-2 (PS-2) in neuroblastoma cells induced apoptotic responses that were inhibited by PTX and restored by expressing a PTX-resistant variant of Gαo but not Gαi (Wolozin et al., 1996; Abe et al., 2004). Here, PSEN2 is linked to neuroblastoma.