The mechanism by which α-syn is incorporated into exosomes is still unknown, but given the vast number of genes linked to PD that have a role in endocytic and autophagy pathways such as PARK2, GBA, LRRK2, or ATP13A2 (Gan-Or et al., 2015), the rapid advancement of research in vesicle trafficking might give some clues in the next years. Here, LRRK2 is linked to Parkinson disease.