Chaudhuri et al. reported that overexpression of miR-125b mediated M1 polarization and increased the response of macrophages to IFN-γ which resulted in higher MHCII, CD40, CD80, and CD86 expression; moreover miR-125b overexpressing RAW264.7 macrophages were more effective killers of EL4 thymoma tumor cell line [131]. The gene discussed is CD40; the disease is neoplasm.