The inflammatory milieu of the tumor microenvironment affects different intracellular master regulators of TAMs such as Signal Transducer and Activator of Transcription factors (STAT3 and STAT6 for M2, STAT1 for M1 polarization), the nuclear factor-κB (NF-κB), RORC1, and HIF-1. This evidence concerns the gene STAT6 and neoplasm.