VEGFA and wet macular degeneration: AMD is the leading cause of blindness in developed countries.2 There were ∼513 000 people living with late AMD in the UK in 2012, and numbers are expected to grow by a third by 2020 with the increasing age of the population.3 There are no proven treatments for dry AMD to date although progression may be reduced with the Age-Related Eye Disease Study 2 (AREDS 2)formula nutritional supplements.4, 5 Significant advances have been made in treatment for wet AMD with intravitreal injections of anti-VEGF drugs.