SLC30A1 and acrodermatitis enteropathica: For example, in mammals, ZnT1 knockout mice die at an embryonic stage, suggesting a key function for ZnT1 in fetal development [29]; hZIP13 mutations have been shown to cause Ehlers–Danlos syndrome [30]; and human ZIP4 has been found to be responsible for acrodermatitis enteropathica (AE), a human inherited disease caused by impaired zinc uptake [31–33].