The human XPO1 gene is located on chromosome 2p15, which is close to the c-REL 2p16.1 locus, a locus well known to be gained or amplified in PMBL, germinal B-cell-like (GCB) diffuse large B cell lymphoma (DLBCL), and cHL. The gene discussed is XPO1; the disease is diffuse large B-cell lymphoma.