Gains at the chromosome 2p16.1-2p15 locus, which contains both the REL and XPO1 genes, were commonly observed in GCB DLBCL, cHL, and PMBL cases [56–58] and may be an important mechanism of XPO1 overexpression in these hematological malignancies. Here, REL is linked to diffuse large B-cell lymphoma.