Interestingly, FTC-133 is a cancer cell line characterized by the mutation of the tumor suppressor gene PTEN (phosphatase and tensin homologue) [26], which makes the transcription factor HIF-1α functionally expressed in thyroid carcinomas independently of lowered oxygen tension, thus promoting apoptosis resistance and tumor cell survival [27]. This evidence concerns the gene HIF1A and thyroid gland carcinoma.