In BPH-1 cells co-cultured with c-Jun-/- fibroblasts and exposed to finasteride, higher expression levels of p-AKT (0.43 versus 0.33, P = 0.06) and p-ERK1/2 (0.21 versus 0.69, P <0.001) were observed (Fig 5). Here, MAPK3 is linked to benign prostatic hyperplasia.