PIK3CA and melanoma: Our cost analysis shows that the panel cost is only slightly higher than this, at £339 (US$449) per sample, and that for certain gene test combinations, such as testing for BRAF, EGFR, KRAS, and PIK3CA (Table 3), sequential single gene testing is actually more expensive than testing several genes at the same time using the panel (£27 for NSCLC and £32 for melanoma).