In keeping with published studies, there were frequent mutations of BRAF and NRAS in melanoma; BRAF, EGFR, KRAS, and STK11 in NSCLC; APC, BRAF, KRAS, and PIK3CA in CRC; KIT and PDGFR3A in GIST; and CTNNB1 in other tumours (desmoid fibromatosis). The gene discussed is PIK3CA; the disease is colorectal carcinoma.