Genes where a statistically significant difference in mutation rate was observed were APC (p = 9 × 10−7) in CRC, STK11 (p = 0.008) in NSCLC, and CDKN2A (p = 0.02), ERBB4 (p = 9 × 10−4), FLT3 (p = 0.02), and KDR (p = 0.01) in melanoma. The gene discussed is ERBB4; the disease is melanoma.