Since SMCR8 and C9ORF72 protein levels are interdependent (Amick et al., 2016) and lysosomal dysfunction was detected in SMCR8 ko cells as well as in C9ORF72 ko mice (Amick et al., 2016; Sullivan et al., 2016), future studies are required to reveal whether SMCR8 plays a role in ALS-FTD alongside with C9ORF72. This evidence concerns the gene SMCR8 and amyotrophic lateral sclerosis.