Furthermore, HF patients with elevated FD levels (i.e., above 1.7 μg/mL), and TCC levels (i.e., above 2.6 CAU/mL), had significantly higher Nt-proBNP and CRP levels (Fig. 3e–h), but had the same LVEF and clinical outcome as HF patients with normal FD levels (data not shown). Here, NPPB is linked to hydrops fetalis.