Therefore, understanding the mechanism underlying the role of NG2 glial cells in the regulation of the immune system in the CNS may highlight the biological importance of maintaining the CNS and lead to the development of new therapeutic approaches for the chronic neuroinflammation that is observed in neurodegenerative diseases, demyelinating diseases, and mental disorders, and the functional deterioration of the CNS due to aging. Here, CSPG4 is linked to demyelinating disease.