Using a cutoff of NES at 2.00, we also identified gene sets that are preferentially enriched in the healthy versus tumour tissues (Supplementary Table 2), for example ‘MYC targets' and ‘G2/M checkpoint' gene sets were enriched in the healthy tissue, whereas ‘Angiogenensis' and ‘tumor necrosis factor alpha (TNFA) signalling via nuclear factor–κB' gene sets were enriched in the tumour tissues (Fig. 4a). This evidence concerns the gene TNF and neoplasm.