In this study, we demonstrate for the first time that: (1) concomitant underexpression of TGFBR2 and overexpression of hTERT were associated with worse prognosis in cervical cancer; (2) knockdown of TGFBR2 promoted cell growth, cell invasion and G1/S transition; but reduced cell apoptosis; (3) downexpression of TGFBR2 led to higher expression of hTERT, TRF2, POT1, TIN2 and TPP1; (4) overexpression of TGFBR2 combined with BIBR1532 significantly inhibited cell growth. Here, POT1 is linked to cervical carcinoma.