Consistent with these observations, the down regulation of let-7 family in atypical meningiomas was correlated with upregulation of EZH2 mRNA expression in our dataset (let-7c: ∼−0.65, P=0.001, let-7d: ∼−0.62, P=0.002, let-7e: ∼−0.49, P=0.02 correlation test) (Fig. 3e). Here, EZH2 is linked to meningioma.