Although active genomic regions as defined by H3K27ac binding were highly correlated among different meningioma samples (with a minimum correlation coefficient of 0.7), we were able to clearly classify meningiomas into atypical versus benign samples as well as into various molecular subgroups, including NF2 CNV-high, NF2 CNV-low and non-NF2 samples (Fig. 5d). This evidence concerns the gene NF2 and meningioma.