Second, for NF2 mutant meningiomas, which also formed 2 different sub-clusters, one of the subgroups revealed a distinct hypermethylated phenotype and was significantly enriched for atypical CNV-high samples (P=0.03 (two NF2 cluster comparison), Fisher’s exact test) (Fig. 4a–c; Supplementary Data 6b). Here, NF2 is linked to meningioma.