We observed the highest enrichment for PRC2-hESCs hypermethylation in the atypical and benign NF2 CNV-high samples (FDR 9.3 × 10−142 when compared with benign non-NF2 mutant samples), followed, in order, by the NF2/SMARCB1, NF2 CNV-low and atypical non-NF2 meningiomas (FDR values 1.2 × 10−91, 4.1 × 10−77 and 2.8 × 10−75 respectively) (Fig. 4e; Supplementary Data 7b–f). The gene discussed is SMARCB1; the disease is meningioma.