Deletions in phosphatase and tensin homologue (PTEN) (10q23) (13% versus 0% in atypical versus benign NF2 tumours, FDR=0.018), myc-associated factor X (MAX) (14q23) (34% versus 10%, FDR=0.03), neurogenic locus notch homolog protein 2 (NOTCH2) (1p13) (20% versus %3, FDR=0.043), AT-rich interactive domain-containing protein 1B (ARID1B) (6q25) (30% versus 10%, FDR=0.058), a member of the SWI/SNF-A chromatin-remodeling complex and cyclin-dependent kinase inhibitor 2C (CDKN2C) (1p32) (46% versus 24%, FDR=0.08) genes were significantly more common in atypical NF2 samples (Fig. 1e). The gene discussed is CDKN2C; the disease is neoplasm.