GNA11 and Hypocalcemia: The Ile62Val Gna11 mutation showed a gene dosage effect with the heterozygous-affected Dsk7/+ mice having an ~0.3 mmol/l decrease in plasma calcium and ~65% reduction in PTH concentrations compared with +/+ mice, whereas homozygous-affected Dsk7/Dsk7 mice have significantly more pronounced hypocalcemia (plasma calcium ~0.5 mmol/l lower than +/+ mice) and a greater (~85%) reduction in PTH concentrations (Figure 1 and Table 1).