PTH and Hypocalcemia: Moreover, we have shown that administration of a single NPS-2143 dose induced a rapid and marked rise in PTH concentrations in Dsk7/+ and Dsk7/Dsk7 mice, and rectified or improved their hypocalcemic phenotypes, respectively (Figure 5); these data suggest that Dsk7/Dsk7 mice will likely require a higher dose of NPS-2143 to correct their hypocalcaemia.