CASR and Hypocalcemia: In contrast, our finding that Dsk7 mice have hypocalcemia and low PTH values in the absence of renal or bone abnormalities suggests that germline Gα11 mutations may influence CaSR signaling responses in the parathyroid gland without perturbing the function of this GPCR in other calcitropic tissues (Figure 1 and Tables 1–3).