VEGFD and bone cancer: Honokiol's effects have been studied in other cancer xenograft models such as overexpressing VEGF-D Lewis lung carcinoma cells [40]; transformed endothelial cell line SVR [2]; Ovarian carcinoma SKOV3 cells [41]; colorectal cancer [16]; head and neck cancer cell lines Cal-33 and 1483 [23]; malignant bone tumor human chondrosarcoma cells [42]; mouse 4T1 breast cancer cells [43]; lung cancer A549 cells [44]; and hepatocellular carcinoma [45].