Interestingly, association between p53 and diabetes-related complications was shown for diabetic cardiomyopathy [203–205], retinopathy [233], neuropathy [234], nephropathy [235], vasculopathy [183], peripheral arterial disease (PAD) [236], defective wound healing [237, 238], testicular dysfunction [239, 240], thrombocytic complications [241], or augmented apoptosis-based response towards ischemia [242]. This evidence concerns the gene TP53 and diabetes mellitus.