Even in studies using HER-2 overexpression, ER and PR status, and Ki67 as surrogate markers for intrinsic subtypes, this results hold true, with bone being the predominant site of metastasis in 66.6% of luminal A-like tumours, 71.4% of the luminal B-like tumours, and 65% of the luminal/HER2-like groups [1, 59]. Here, ERBB2 is linked to neoplasm.