While the univariate analysis identified peanut-specific IgE, total IgE, male sex, asthma, and IL-5, IL-9 and IL-13 responses to peanut as being significant predictors of clinical reactivity, subsequent multivariable analyses found these variables to be related to peanut SPT wheal size and thus when entered into a model with wheal size were non-significant. The gene discussed is IGHE; the disease is asthma.