The clinical relevance of our findings is illustrated by the post hoc analysis in which we determined that only one in 16 asthma participants changed their periostin classification between ‘high periostin’ and ‘low periostin’, based on the 0800 and 1800 h levels, utilizing the proposed periostin cut point of 50 ng/mL, used to determine responsiveness to monoclonal antibody therapy directed against IL-13 [9], and IgE [10]. Here, POSTN is linked to asthma.