The previous studies explained our finding of a significant positive correlation between the expression of NEDD9 and p38 protein (p = 0.007), indicating that there are synergistic effects between them during the development of invasion and metastases of transitional cell carcinoma of the urinary bladder; also their pattern and intensity of expression together can help to detect the prognosis of transitional cell carcinoma and predict patient outcome and survival. The gene discussed is NEDD9; the disease is bladder transitional cell carcinoma.