ERVW-1 and HIV infectious disease: Untreated chronic HIV infection results in selective accumulation of TFh cells in lymph nodes (35); Lindqvist et al. have demonstrated the relative accumulation of HIV-specific TFh cells in lymph nodes during chronic untreated HIV infection that was associated with HIV viremia, interestingly the majority of the expanded TFh cells were specific for Gag, as opposed to Env (36).