While 7-36a exerts cardiovascular effects in a GLP-1R-dependent fashion, mainly improving myocardial glucose uptake, 9-36a acts through GLP-1R-independent processes, largely accounting for vasodilation, amelioration of endothelial dysfunction, increased cardiac function, and cytoprotection against ischemic-reperfusion injury. Here, GLP1R is linked to endothelial dysfunction.