INS and type 2 diabetes mellitus: Interestingly, in a single-blind random crossover study, subjects underwent intravenous infusion of human recombinant GLP-1 for 105 min and had their endothelial function and insulin sensitivity measured with ultrasonography through flow-mediated vasodilation (FMD) and hyperinsulinemic isoglycemic clamp technique, respectively; 7-36a increased the FMD response and relatively (16%), albeit not significantly, affected insulin sensitivity in T2DM subjects, without any effects on FMD and insulin sensitivity in healthy subjects (Nyström et al., 2004).