GLP1R and type 2 diabetes mellitus: This seems inconsistent with previous studies, which demonstrated an improvement in insulin sensitivity with a 6 week course of 7-36a in patients with T2DM (Zander et al., 2002), however, it cannot be excluded that during this very short time (105 min) GLP-1 may not affect insulin sensitivity, and the beneficial endothelial effects of GLP-1 in patients with T2DM were not fully dependent on improvements in insulin sensitivity.