Interestingly, in a single-blind random crossover study, subjects underwent intravenous infusion of human recombinant GLP-1 for 105 min and had their endothelial function and insulin sensitivity measured with ultrasonography through flow-mediated vasodilation (FMD) and hyperinsulinemic isoglycemic clamp technique, respectively; 7-36a increased the FMD response and relatively (16%), albeit not significantly, affected insulin sensitivity in T2DM subjects, without any effects on FMD and insulin sensitivity in healthy subjects (Nyström et al., 2004). This evidence concerns the gene GLP1R and type 2 diabetes mellitus.