Sung et al. (2009) found zerumbone to inhibit receptor activator for NF-kB ligand (RANKL) induced NF-κB activation in the mouse monocytes through the suppression of activation of IκBα kinase, IκBα degradation and IκBα phosphorylation as well as found to suppress osteoclast formation induced by human breast tumor cell lines. The gene discussed is NFKBIA; the disease is breast neoplasm.