KDM5C and Huntington disease: Moreover, KDM5C/JARID1C, an enzyme involved in demethylation of H3K4me3, was up-regulated in the striatum and cortex of HD R6/2 mice and proposed to contribute to decreased H3K4me3 in HD brain tissues (Ng et al., 2013; Vashishtha et al., 2013) (Figure 4).