AFP and neoplasm: Of these, most were derived from the metastatic lesions of GBC patients, such as NOZ, OCUG-1, FU-GBC-2 and EH-GB1 from the ascites or the abdominal wall [11, 13, 21], TYGBK-1 from a lymph node [24], and EH-GB2 from liver metastatic site [23]; some were derived from primitive cultured tumor that planted in nude mice [18]; whereas others had themselves features, for example, GBK-1 was derived from human colony stimulating factor-producing GBC [9], KMG-A from AFP-producing GBC [10], and PTHrP-GBK from parathyroid hormone-related peptide producing GBC [16].