HSF1 and Huntington disease: Increased Fbxw7 protein levels were observed in STHdhQ111 cells, KIQ175 mice and HD patients (Fig. 2g–i; Supplementary Fig. 2A,B,E) and correlated with increased HSF1 S303/307 phosphorylation and low HSF1 protein levels and activity (Figs 1b–f,i and 2e; Supplementary Fig. 1G).