HSF1 and Huntington disease: Given the dramatic elevation in CK2α′ levels in HD models and patients, mice heterozygous for CK2α′ (CK2α′+/−) were generated in the KIQ175 background to evaluate the impact on HSF1 levels, activity and on the neuropathology observed in this HD model (Fig. 7a and Supplementary Fig. 6B).