FLT3 was co-expressed with other driver genes in the sub-network, including WDFY4 and FAT4. Moreover, three recurrently deregulated lncRNAs (HAND2-AS1, AC096579.7 and FENDRR) were strongly correlated with FLT3 at the expression level, suggesting that these lncRNAs have functions related to that of FLT3. Another interesting gene in cluster 25, FAT4, encodes a cadherin (a calcium-dependent cell adhesion protein) that serves as a tumour-suppressor gene41. Here, HAND2 is linked to neoplasm.