Three known ESCC lncRNAs, comprising HOTAIR,15 ANRIL,16 and SOX2OT,17 showed statistically significantly differential expression between tumor and non-tumor samples (FDR values of DESeq were 5.51E-05, 0.0048 and 0.21, respectively). The gene discussed is SOX2-OT; the disease is esophageal squamous cell carcinoma.