Thus, we focused on 48 histone modification related proteins reported to be highly associated with ESCC.50 LncRNA625-regulated PCGs were potentially regulated by 176 transcription-related regulatory proteins based on transcription protein analysis using the DAVID tool.51 Interestingly, of these 48 ESCC histone modification proteins, only the E1a-binding protein p300 (EP300) appeared in 176 lncRNA625-related transcription regulatory proteins (Figure 5b). The gene discussed is EP300; the disease is esophageal squamous cell carcinoma.