EP300 and cancer: Indeed, most of lncRNA625- and EP300-induced downstream PCGs evaluated by qRT–PCR are known positive regulators of cancer, including NEK6,35, 36, 37, 38 TNC,39, 40 CCNG1,41 HIST1H2BM,42 NCOA443 and KCTD12.44 These results demonstrate the key role of EP300 in executing lncRNA625-induced transcriptional responses of genes, to promote cancer cell proliferation, invasion and migration.