The lncRNA in lung cancer tissues is significantly higher compared with paired adjacent normal lung tissues.31 Moreover, DLX6-AS1 might be a novel therapeutic target for lung cancer patients because it appears to enhance cancer invasion and metastasis.31 Taken together, the top-ranked lncRNAs, identified by URW-LPE, have potential to have novel functional roles in ESCC. This evidence concerns the gene DLX6 and lung carcinoma.