It has been reported that p204, a mouse orthologue of IFI16, cooperates with cGAS during Francisella novicida infection in murine RAW264.7 monocytic cells20, and synergy between IFI16 and cGAS has also been observed during Listeria monocytogenes infection in human myeloid cells, and during HSV-1 infection in primary human foreskin fibroblasts15, 19, using RNAi approaches to study the effect of IFI16 and cGAS depletion. The gene discussed is IFI16; the disease is listeriosis.