In summary, although it is important to note that our study is limited to the characterization of the early changes (first 24 h) that occur after ischaemic insult thus not being able to determine potential protective long-term effects of fructokinase blockade in kidney disease (i.e., fibrosis, renal dysfunction, aging-associated kidney disease, etc), our data indicate that in ischaemic AKI, there is an important generation and metabolism of fructose in the kidney cortex that correlates with the development of renal injury and dysfunction. This evidence concerns the gene KHK and aging.