Contrast-induced nephropathy (CIN) is one of the most important causes of AKI in the clinic, and of interest, the main risk factors (hyperglycaemia, hypertonicity as radiocontrast agents and hypoxia) are very well-established activators of aldose reductase and the polyol pathway. Here, AKR1B1 is linked to cervical squamous intraepithelial neoplasia.