Furthermore, compared with WT and Trp53-null luminal MECs (that is, from mice4 weeks after induction), all these tumours, in particular the Type 1 tumours, exhibited lower expression levels of multiple Claudin genes (for example, Cldn3, Cldn4, Cldn7), and higher expression levels of many EMT-related genes (for example, Twist1, Zeb1, Cdh2 and Vim; Fig. 4f). Here, CLDN3 is linked to neoplasm.