TP53 and breast carcinoma: Although mutations in the p53 gene (TP53 in human, Trp53 in mouse) have been found in all breast cancer subtypes, they are particularly prevalent in TNBCs: for instance, TP53 mutations (largely inactivation mutations) have been found in at least 80% ofbasal-like breast cancer (BLBC) cases2; in claudin-low breast cancer, the 17p13.1-p12 genomic region, which harbours TP53, is also frequently deleted8.