PRRC2C and Intellectual disability: DRD2 encodes a dopamine receptor and has previously been associated with psychiatric illnesses.63 Alternative splicing of PRRC2C has been associated with lung cancer.64 Mutations in ANO10 cause cerebellar ataxias.65ASXL3 encodes a polycomb protein and mutations in this gene are associated with intellectual disability, feeding problems and distinctive facial features.66