More importantly, researcher examined 154 esophageal cancer tissue samples and found that simultaneous high expression of CD133 and CXCR4 was significantly correlated with shortened disease-free survival and overall survival in patients, suggesting that high expression of CXCR4 on CD133+ esophageal cancer stem cells was significantly correlated with poor prognosis [14]. This evidence concerns the gene CXCR4 and esophageal cancer.