Since Add3 is a candidate gene for the development of renal disease in FHH rats, and MNS rats share the same variant in Add3 as FHH rats, this study tested whether an impairment in the myogenic response of the Af‐Art may be associated with the susceptibility of MNS to develop proteinuria and renal injury as they age and following induction of diabetes with STZ. This evidence concerns the gene ADD3 and diabetes mellitus.