NFE2L2 and Carcinoma, Lewis Lung: NRF2 regulates the expression of several antioxidant genes such as NADPH, NQO1 and hemeoxygenase and increased expression of NRF2 results in a reduction of intracellular ROS and attenuates MDSC-driven immunosuppression (Thimmulappa et al. 2007, Nagaraj et al. 2010, Marvel & Gabrilovich 2015), whereas deletion of NRF2 was reported to increase metastasis in mice with Lewis lung carcinoma due to the aberrant accumulation of ROS in MDSC (Hiramoto et al. 2014).