HUWE1 and colonic neoplasm: Moreover, rather high overall cellular concentrations of HUWE1 have been reported, based on quantitative proteomics studies, for instance 120 nM in colon tissue (Wiśniewski et al., 2015a), 250 nM in colon cancer tissue (Wiśniewski et al., 2015a), and 400 nM in MCF7 cells (Wiśniewski et al., 2015b).